Alexion Pharmaceuticals Research Associate IV, Discovery Research in New Haven, Connecticut

Position Summary

The Research Associate IV will serve on cross-functional teams and contribute to the discovery of protein therapeutics to treat rare diseases. The successful candidate will be responsible for the production and in vitro characterization of therapeutic proteins to enable candidate selection.

Principal Responsibilities

  • Mammalian cell culture and transient protein expression

  • Management of a cell culture lab

  • Maintenance of DNA / protein inventory

  • Experimental design and data interpretation

  • Characterization of the functional and biophysical properties of recombinant proteins

  • Meticulous record keeping, generation of technical reports and presentation of data


  • Proficiency in protein production and characterization:

  • Mammalian cell culture and transient protein expression

  • Protein purification

  • SDS-PAGE/ Western Blot

  • Thermal stability; fluorescence / light scattering

  • HPLC

  • Binding and inhibition assays

  • DNA/protein sequence analysis

  • Ability to work with minimal supervision

  • Excellent communication / collaboration skills

  • Highly organized with attention to detail


  • cell biology, molecular biology, pharmacology or other biomedical science with at least 3 years of relevant experience, or a B.S. with at least 5 years of relevant experience, preferably in a pharmaceutical or biotechnology setting.


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Some opportunities happen only once in a lifetime - like a job where you have the extraordinary opportunity to change lives. At Alexion, such opportunities arise through our unwavering mission to serve patients and families affected by rare diseases. These patients are our guiding star, and we act with integrity, urgency, and discipline because we know their lives are at stake.

Alexion is a global biopharmaceutical company focused on serving patients and families affected by rare diseases through the discovery, development and commercialization of life-changing therapies. As the global leader in complement biology and inhibition for more than 20 years, Alexion has developed and commercializes the first and only approved complement inhibitor to treat patients with paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and anti-acetylcholine receptor (AchR) antibody-positive generalized myasthenia gravis (gMG). Alexion also has two highly innovative enzyme replacement therapies for patients with life-threatening and ultra-rare metabolic disorders, hypophosphatasia (HPP) and lysosomal acid lipase deficiency (LAL-D). In addition, the company is developing two late-stage therapies, a second complement inhibitor and a copper-binding agent for Wilson disease. Alexion focuses its research efforts on novel molecules and targets in the complement cascade and its development efforts on the core therapeutic areas of hematology, nephrology, neurology, and metabolic disorders. Alexion has been named to the Forbes list of the World's Most Innovative Companies seven years in a row and is headquartered in Boston, Massachusetts' Innovation District. The company also has offices around the globe and serves patients in more than 50 countries.

Alexion's aspiration is to be the most rewarding place to work, where people are empowered to make a difference and where diversity of backgrounds and ideas is encouraged. We are looking for talented individuals who share our passion and commitment to change the lives of patients with rare diseases. We hope you will consider joining our team. Further information about Alexion can be found at:

As a leading employer in our industry, Alexion is proud to offer a highly competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more.