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Dana-Farber Cancer Institute Research Fellow in Boston, Massachusetts

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

This is a position in Matthew Meyerson’s laboratory at Dana-Farber, involving the study of the cancer microbiome in colorectal cancer; its interactions with tumor, immune and other host cells; its impact on the efficacy of cancer treatment; and the development of novel approaches to treat colorectal cancers by manipulating the cancer microbiota.

The Meyerson lab was the first to identify the association of Fusobacterium nucleatum with a subset of human colorectal cancers (Kostic et al., Genome Research, 2012, 22(2): 292–298). This work, published in parallel with Rob Holt’s group that made the same discovery independently (Castellarin et al., Genome Research, 2012, 22(2): 299–306), led to further investigations describing the potential of F. nucleatum to accelerate intestinal tumorigenesis in mouse models (Kostic et al., Cell Host Microbe, 2013, 14(2): 207–215) and, most recently, to the discovery that Fusobacterium and its associated microbiota persist in colorectal cancers through the metastatic process and that antibiotic treatment of mice bearing Fusobacterium-containing human tumor xenografts diminishes tumor growth (Bullman et al., Science, 2017, 358(6369): 1443-1448).

Note: We request that candidates please apply only through the Dana-Farber careers website and not contact the Principal Investigator directly. Please include the names of 2-3 references in your application.

Qualifications

Required qualifications:

  • A PhD in Microbiology/Microbial Genomics/Cancer Biology/Computational Biology/Life Sciences or related field.

  • A collaborative, curious, creative, proactive and organized temperament.

  • A commitment to advancing fundamental knowledge of the cancer microbiome and to translating that knowledge to the development of novel therapeutic approaches.

Additional qualifications:

  • Proficiency in experimental microbiology techniques, including isolation and culture of bacteria from tissue specimens, including species that are challenging to culture, genetic manipulation of microorganisms, etc., would be extremely useful.

  • Experience with mouse models of cancer or other diseases would be a plus.

  • Computational and “omics” experience, including knowledge of metagenomics/metatranscriptomics/proteomics/metabolomics welcomed but not essential.

Job ID: 2019-12832

Grade: 41

External Company URL: www.dana-farber.org

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