Dana-Farber Cancer Institute Research Fellow in Boston, Massachusetts
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
This is a position in Matthew Meyerson’s laboratory at Dana-Farber, involving the study of the cancer microbiome in colorectal cancer; its interactions with tumor, immune and other host cells; its impact on the efficacy of cancer treatment; and the development of novel approaches to treat colorectal cancers by manipulating the cancer microbiota.
The Meyerson lab was the first to identify the association of Fusobacterium nucleatum with a subset of human colorectal cancers (Kostic et al., Genome Research, 2012, 22(2): 292–298). This work, published in parallel with Rob Holt’s group that made the same discovery independently (Castellarin et al., Genome Research, 2012, 22(2): 299–306), led to further investigations describing the potential of F. nucleatum to accelerate intestinal tumorigenesis in mouse models (Kostic et al., Cell Host Microbe, 2013, 14(2): 207–215) and, most recently, to the discovery that Fusobacterium and its associated microbiota persist in colorectal cancers through the metastatic process and that antibiotic treatment of mice bearing Fusobacterium-containing human tumor xenografts diminishes tumor growth (Bullman et al., Science, 2017, 358(6369): 1443-1448).
Note: We request that candidates please apply only through the Dana-Farber careers website and not contact the Principal Investigator directly. Please include the names of 2-3 references in your application.
A PhD in Microbiology/Microbial Genomics/Cancer Biology/Computational Biology/Life Sciences or related field.
A collaborative, curious, creative, proactive and organized temperament.
A commitment to advancing fundamental knowledge of the cancer microbiome and to translating that knowledge to the development of novel therapeutic approaches.
Proficiency in experimental microbiology techniques, including isolation and culture of bacteria from tissue specimens, including species that are challenging to culture, genetic manipulation of microorganisms, etc., would be extremely useful.
Experience with mouse models of cancer or other diseases would be a plus.
Computational and “omics” experience, including knowledge of metagenomics/metatranscriptomics/proteomics/metabolomics welcomed but not essential.
Job ID: 2019-12832
External Company URL: www.dana-farber.org